ea0020htc3 | Hot topics: Clinical | ECE2009
Assie Guillaume
, de Reynies Aurelien
, Rickman David
, Tissier Frederique
, Groussin Lionel
, Rene-Corail Fernande
, Dousset Bertrand
, Bertagna Xavier
, Clauser Eric
, Bertherat Jerome
Diagnosing malignancy and assessing the prognosis of adrenocortical tumors is challenging. The aim is to identify molecular predictors of malignancy and of survival.Patients and methods: Of 153 unilateral adrenocortical tumors were studied by microarray (n=92) or RT-qPCR (n=148). A 2-gene predictor of malignancy was built using the disease-free survival as the end-point in a training cohort (n=47), then validated in an independent va...